[HTML][HTML] A novel ubiquitin-like domain in IκB kinase β is required for functional activity of the kinase
Activation of NF-κB requires two highly related kinases named IKKα and IKKβ that share
identity in the nature and positioning of their structural domains. Despite their similarity, the
kinases are functionally divergent, and we therefore sought to identify any structural features
specific for IKKα or IKKβ. We performed bioinformatics analysis, and we identified a region
resembling a ubiquitin-like domain (UBL) that exists only in IKKβ and that we named the
UBL-like domain (ULD). Deletion of the ULD rendered IKKβ catalytically inactive and unable …
identity in the nature and positioning of their structural domains. Despite their similarity, the
kinases are functionally divergent, and we therefore sought to identify any structural features
specific for IKKα or IKKβ. We performed bioinformatics analysis, and we identified a region
resembling a ubiquitin-like domain (UBL) that exists only in IKKβ and that we named the
UBL-like domain (ULD). Deletion of the ULD rendered IKKβ catalytically inactive and unable …