Say when: reversible control of gene expression in the mouse by lac
H Scrable - Seminars in cell & developmental biology, 2002 - Elsevier
H Scrable
Seminars in cell & developmental biology, 2002•ElsevierIn bacteria, coordinate expression of genes involved in lactose metabolism is regulated by
the lac repressor and its DNA binding sequence, the lac operator. The lac operator–
repressor complex can also be used to regulate gene expression in the laboratory mouse. In
this review, I discuss the current state of murine trans-operons, and suggest ways this lac-
based system might be used to build more advanced models of human diseases in the
mouse.
the lac repressor and its DNA binding sequence, the lac operator. The lac operator–
repressor complex can also be used to regulate gene expression in the laboratory mouse. In
this review, I discuss the current state of murine trans-operons, and suggest ways this lac-
based system might be used to build more advanced models of human diseases in the
mouse.
In bacteria, coordinate expression of genes involved in lactose metabolism is regulated by the lac repressor and its DNA binding sequence, the lac operator. The lac operator–repressor complex can also be used to regulate gene expression in the laboratory mouse. In this review, I discuss the current state of murine trans-operons, and suggest ways this lac-based system might be used to build more advanced models of human diseases in the mouse.
Elsevier
