Tubular epithelial NF-κB activity regulates ischemic AKI
L Markó, E Vigolo, C Hinze, JK Park… - Journal of the …, 2016 - journals.lww.com
NF-κB is a key regulator of innate and adaptive immunity and is implicated in the
pathogenesis of AKI. The cell type–specific functions of NF-κB in the kidney are unknown;
however, the pathway serves distinct functions in immune and tissue parenchymal cells. We
analyzed tubular epithelial-specific NF-κB signaling in a mouse model of ischemia-
reperfusion injury (IRI)–induced AKI. NF-κB reporter activity and nuclear localization of
phosphorylated NF-κB subunit p65 analyses in mice revealed that IRI induced widespread …
pathogenesis of AKI. The cell type–specific functions of NF-κB in the kidney are unknown;
however, the pathway serves distinct functions in immune and tissue parenchymal cells. We
analyzed tubular epithelial-specific NF-κB signaling in a mouse model of ischemia-
reperfusion injury (IRI)–induced AKI. NF-κB reporter activity and nuclear localization of
phosphorylated NF-κB subunit p65 analyses in mice revealed that IRI induced widespread …