Prevention of acute experimental pancreatitis in rats and dogs by intraduodenal infusion of a synthetic trypsin inhibitor
S Takasugi, H Yonezawa, N Ikei, T Kanno - Digestion, 1982 - karger.com
S Takasugi, H Yonezawa, N Ikei, T Kanno
Digestion, 1982•karger.comAcute hemorrhagic pancreatitis was induced in rats and dogs by a closed duodenal loop
method. All dogs and most of the rats died of acute pancreatitis within 18 h after the
operation. Infusion of a synthetic trypsin inhibitor into the lumen of the closed duodenal loop
not only prevented development of acute pancreatitis in these animals, but they survived
without any acute signs of the disease. As elevation of amylase activity in the pancreata of
rats and in the plasma of dogs is not always associated with the development of acute …
method. All dogs and most of the rats died of acute pancreatitis within 18 h after the
operation. Infusion of a synthetic trypsin inhibitor into the lumen of the closed duodenal loop
not only prevented development of acute pancreatitis in these animals, but they survived
without any acute signs of the disease. As elevation of amylase activity in the pancreata of
rats and in the plasma of dogs is not always associated with the development of acute …
Abstract
Acute hemorrhagic pancreatitis was induced in rats and dogs by a closed duodenal loop method. All dogs and most of the rats died of acute pancreatitis within 18 h after the operation. Infusion of a synthetic trypsin inhibitor into the lumen of the closed duodenal loop not only prevented development of acute pancreatitis in these animals, but they survived without any acute signs of the disease. As elevation of amylase activity in the pancreata of rats and in the plasma of dogs is not always associated with the development of acute pancreatitis, esterolytic activity may thus be a superior index of this entity.
Karger