Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r, and C1 esterase
Y Tamura, M Hirado, K Okamura, Y Minato… - Biochimica et Biophysica …, 1977 - Elsevier
Abstract p-Carbethoxyphenyl ε-guanidinocaproate and p-(p′-guanidinobenzoyloxy)-phenyl
derivatives were prepared, and their inhibitory effects on trypsin, plasmin, plasma kallikrein,
thrombin, C 1 r and C 1 esterase were examined. Among the various inhibitors tested, p-
nitrophenylp′-guanidinobenzoate, N, N-dimethylamino p-(p′-guanidinobenzoyloxy)-
benzoyl glycolate and N, N-dimethylaminop-(p′-guanidinobenzoyloxy)-benzilcarbonyloxy
glycolate were the most effective inhibitors of trypsin, plasmin, plasma kallikrein and …
derivatives were prepared, and their inhibitory effects on trypsin, plasmin, plasma kallikrein,
thrombin, C 1 r and C 1 esterase were examined. Among the various inhibitors tested, p-
nitrophenylp′-guanidinobenzoate, N, N-dimethylamino p-(p′-guanidinobenzoyloxy)-
benzoyl glycolate and N, N-dimethylaminop-(p′-guanidinobenzoyloxy)-benzilcarbonyloxy
glycolate were the most effective inhibitors of trypsin, plasmin, plasma kallikrein and …