Abstract T7K24R mice carry mutation p. K24R in mouse cationic trypsinogen (isoform T7),
which is analogous to the human hereditary pancreatitis-associated mutation p. K23R. The
mutation renders trypsinogen more prone to autoactivation. We recently reported that
T7K24R mice exhibit increased severity of acute pancreatitis induced by repeated cerulein
injections. The objective of the present study was to test whether trypsinogen mutant mice
are prone to develop chronic pancreatitis, as observed in patients. We characterized the …