The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the
predominant pathways responsible for the synthesis of the most abundant phospholipids,
phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian
membranes. Recently, hereditary diseases associated with single gene mutations in the
Kennedy pathways have been identified. Interestingly, genetic diseases within the same
pathway vary greatly, ranging from muscular dystrophy to spastic paraplegia to a childhood …