Adhesion GPCR function in pulmonary development and disease
MG Ludwig, K Seuwen, JP Bridges - Adhesion G Protein-coupled …, 2016 - Springer
MG Ludwig, K Seuwen, JP Bridges
Adhesion G Protein-coupled Receptors: Molecular, Physiological and …, 2016•SpringerGraphical Abstract Abstract Classic G-protein-coupled receptors (GPCRs) control multiple
aspects of pulmonary physiology as demonstrated by loss-of-function experiments in mice
and pharmacologic targeting of GPCRs for treatment of several pulmonary diseases.
Emerging data demonstrate critical roles for members of the adhesion GPCR (aGPCR)
family in pulmonary development, homeostasis, and disease. Although this field is still in its
infancy, this chapter will review all available data regarding aGPCRs in pulmonary biology …
aspects of pulmonary physiology as demonstrated by loss-of-function experiments in mice
and pharmacologic targeting of GPCRs for treatment of several pulmonary diseases.
Emerging data demonstrate critical roles for members of the adhesion GPCR (aGPCR)
family in pulmonary development, homeostasis, and disease. Although this field is still in its
infancy, this chapter will review all available data regarding aGPCRs in pulmonary biology …
Graphical Abstract
Abstract
Classic G-protein-coupled receptors (GPCRs) control multiple aspects of pulmonary physiology as demonstrated by loss-of-function experiments in mice and pharmacologic targeting of GPCRs for treatment of several pulmonary diseases. Emerging data demonstrate critical roles for members of the adhesion GPCR (aGPCR) family in pulmonary development, homeostasis, and disease. Although this field is still in its infancy, this chapter will review all available data regarding aGPCRs in pulmonary biology, with a particular focus on the aGPCR for which the most substantial data to date exist: Adgrf5.
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