[HTML][HTML] Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation
Ischemia reperfusion (I/R) injury following lung transplantation is exacerbated by the
destruction of the endothelial cell barrier leading to pulmonary edema and dysregulated
activated lymphocyte migration. Sphingosine 1-phosphate (S1P), a G-coupled protein
receptor (GPCR) agonist, has been previously shown to promote endothelial cell tight
junction formation and prevent monocyte chemotaxis. We asked if S1P treatment could
improve pulmonary function and attenuate I/R injury following syngeneic rat lung …
destruction of the endothelial cell barrier leading to pulmonary edema and dysregulated
activated lymphocyte migration. Sphingosine 1-phosphate (S1P), a G-coupled protein
receptor (GPCR) agonist, has been previously shown to promote endothelial cell tight
junction formation and prevent monocyte chemotaxis. We asked if S1P treatment could
improve pulmonary function and attenuate I/R injury following syngeneic rat lung …
