Extracellular vesicles as a novel source of biomarkers in liquid biopsies for monitoring cancer progression and drug resistance

MH Vasconcelos, HR Caires, A Ābols… - Drug Resistance …, 2019 - Elsevier
Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and
other biofluids of cancer patients. They carry various tumor-derived molecules such as
mutated DNA and RNA fragments, oncoproteins as well as miRNA and protein signatures
associated with various phenotypes. The molecular cargo of EVs partially reflects the
intracellular status of their cellular origin, however various sorting mechanisms lead to the
enrichment or depletion of EVs in specific nucleic acids, proteins or lipids. It is becoming …