We screened cell line and plasma-derived exosomes for molecules that localize to
mitochondria or that reflect mitochondrial integrity. SH-SY5Y cell-derived exosomes
contained humanin, citrate synthase, and fibroblast growth factor 21 protein, and plasma-
derived exosomes contained humanin, voltage-dependent anion-selective channel 1, and
transcription factor A protein. Nuclear mitochondrial (NUMT) DNA complicated analyses of
mitochondrial DNA (mtDNA), which otherwise suggested exosomes contain at most very low …