Pathophysiology of vascular calcification: pivotal role of cellular senescence in vascular smooth muscle cells
DGA Burton, H Matsubara, K Ikeda - Experimental gerontology, 2010 - Elsevier
The accumulation of senescent cells within tissues can potentially lead to biological
dysfunction and manifestation of disease associated with ageing. The majority of senescent
cells display a commonly altered secretome similar to a wound healing response (termed
the senescence-associated secretory phenotype or SASP), which could have deleterious
implications on the tissue microenvironment. However, senescent cells also appear to have
a cell-type (or even cell-strain) exclusive senescent phenotype (CESP), an area of research …
dysfunction and manifestation of disease associated with ageing. The majority of senescent
cells display a commonly altered secretome similar to a wound healing response (termed
the senescence-associated secretory phenotype or SASP), which could have deleterious
implications on the tissue microenvironment. However, senescent cells also appear to have
a cell-type (or even cell-strain) exclusive senescent phenotype (CESP), an area of research …
