Tissue factor facilitates wound healing in human airway epithelial cells

MD Davis, I Suzaki, S Kawano, K Komiya, Q Cai, Y Oh… - Chest, 2019 - Elsevier
Background Tissue factor (TF) canonically functions as the initiator of the coagulation
cascade. TF levels are increased in inflamed airways and seem to be important for tumor
growth and metastasis. We hypothesized that airway epithelia release TF as part of a wound
repair program. Objectives The goal of this study was to evaluate whether airway epithelia
release TF in response to pro-inflammatory stimuli and to investigate roles of TF in cell
growth and repair. Methods Airway epithelial cells were exposed to 10 μg/mL of …