[HTML][HTML] The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-β1
The balance between matrix metalloproteinases (MMPs) and their inhibitors, the tissue
inhibitors of metalloproteinases (TIMPs), is pivotal in the remodeling of extracellular matrix.
TGF-β has profound effects on extracellular matrix homeostasis, in part via its ability to alter
this balance at the level of gene expression. The intracellular signaling pathways by which
TGF-β mediates its actions include the Smad pathway, specific to the TGF-β superfamily, but
also, for example, mitogen-activated protein kinase pathways; furthermore, cross-talk …
inhibitors of metalloproteinases (TIMPs), is pivotal in the remodeling of extracellular matrix.
TGF-β has profound effects on extracellular matrix homeostasis, in part via its ability to alter
this balance at the level of gene expression. The intracellular signaling pathways by which
TGF-β mediates its actions include the Smad pathway, specific to the TGF-β superfamily, but
also, for example, mitogen-activated protein kinase pathways; furthermore, cross-talk …