[HTML][HTML] Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

BR Conway, ED O'Sullivan, C Cairns… - Journal of the …, 2020 - journals.lww.com
Background Little is known about the roles of myeloid cell subsets in kidney injury and in the
limited ability of the organ to repair itself. Characterizing these cells based only on surface
markers using flow cytometry might not provide a full phenotypic picture. Defining these cells
at the single-cell, transcriptomic level could reveal myeloid heterogeneity in the progression
and regression of kidney disease. Methods Integrated droplet–and plate-based single-cell
RNA sequencing were used in the murine, reversible, unilateral ureteric obstruction model …