[HTML][HTML] Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity
JF Lee, Q Zeng, H Ozaki, L Wang, AR Hand… - Journal of biological …, 2006 - ASBMB
In this report, sphingosine-1-phosphate (S1P), a serum-borne bioactive lipid, is shown to
activate tight-junction-associated protein Zonula Occludens-1 (ZO-1), which in turn plays a
critical role in regulating endothelial chemotaxis and barrier integrity. After S1P stimulation,
ZO-1 was redistributed to the lamellipodia and cell-cell junctions via the S1P1/G i/Akt/Rac
pathway. Similarly, both endothelial barrier integrity and cell motility were significantly
enhanced in S1P-treated cells through the G i/Akt/Rac pathway. Importantly, S1P-enhanced …
activate tight-junction-associated protein Zonula Occludens-1 (ZO-1), which in turn plays a
critical role in regulating endothelial chemotaxis and barrier integrity. After S1P stimulation,
ZO-1 was redistributed to the lamellipodia and cell-cell junctions via the S1P1/G i/Akt/Rac
pathway. Similarly, both endothelial barrier integrity and cell motility were significantly
enhanced in S1P-treated cells through the G i/Akt/Rac pathway. Importantly, S1P-enhanced …