Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
BK Lipska, A Deep-Soboslay, CS Weickert, TM Hyde… - Biological …, 2006 - Elsevier
BACKGROUND: Studies of postmortem human brain are important for investigating
underlying pathogenic molecular mechanisms of neuropsychiatric disorders. They are,
however, confounded by pre-and postmortem factors. The purpose of this study was to
identify sources of variation that will enable a better design of gene expression studies and
higher reliability of gene expression data. METHODS: We assessed the contribution of
multiple variables to messenger RNA (mRNA) expression of reference (housekeeping) …
underlying pathogenic molecular mechanisms of neuropsychiatric disorders. They are,
however, confounded by pre-and postmortem factors. The purpose of this study was to
identify sources of variation that will enable a better design of gene expression studies and
higher reliability of gene expression data. METHODS: We assessed the contribution of
multiple variables to messenger RNA (mRNA) expression of reference (housekeeping) …
