Importance The treatment of multiple brain metastases (MBM) from melanoma is
controversial and includes surgical resection, stereotactic radiosurgery (SRS), and whole-
brain radiation therapy (WBRT). Several new classes of agents have revolutionized the
treatment of metastatic melanoma, allowing some subsets of patients to have long-term
survival. Given this, management of MBM from melanoma is continually evolving. Objective
To review the current evidence regarding the treatment of MBM from melanoma. Evidence …