The microbiome and rheumatoid arthritis
AS Bergot, R Giri, R Thomas - Best practice & research Clinical …, 2019 - Elsevier
Rheumatoid Arthritis (RA) is a severe, chronic autoimmune disease that affects 1% of the
world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest
risks seen in first-degree relatives. Smoking increases the risk of developing anti-
citrullinated peptide antibody (ACPA)+ RA, particularly in individuals with high-risk RA-
susceptibility alleles. Other contributory environmental risks including particulate exposure,
periodontal disease, bronchiectasis, diet, obesity and the oral contraceptive impact …
world's population. Familial risk contributes 50% of the risk of seropositive RA, with strongest
risks seen in first-degree relatives. Smoking increases the risk of developing anti-
citrullinated peptide antibody (ACPA)+ RA, particularly in individuals with high-risk RA-
susceptibility alleles. Other contributory environmental risks including particulate exposure,
periodontal disease, bronchiectasis, diet, obesity and the oral contraceptive impact …