NAT8 variants, N-acetylated amino acids, and progression of CKD
S Luo, A Surapaneni, Z Zheng, EP Rhee… - Clinical Journal of the …, 2021 - journals.lww.com
Results Of 31 N-acetylated amino acids evaluated, the circulating and urinary levels of 14
were associated with rs13538 (P< 0.05/31). Higher circulating levels of five of these N-
acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-
methylhistidine, N-acetylhistidine, and N2, N5-diacetylornithine, were associated with kidney
failure, after adjustment for confounders and combining results in meta-analysis (combined
hazard ratios per two-fold higher amino acid levels: 1.48, 1.44, 1.21, 1.65, and 1.41 …
were associated with rs13538 (P< 0.05/31). Higher circulating levels of five of these N-
acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-
methylhistidine, N-acetylhistidine, and N2, N5-diacetylornithine, were associated with kidney
failure, after adjustment for confounders and combining results in meta-analysis (combined
hazard ratios per two-fold higher amino acid levels: 1.48, 1.44, 1.21, 1.65, and 1.41 …