A metabolome-wide association study of kidney function and disease in the general population
P Sekula, ON Goek, L Quaye, C Barrios… - Journal of the …, 2016 - journals.lww.com
Small molecules are extensively metabolized and cleared by the kidney. Changes in serum
metabolite concentrations may result from impaired kidney function and can be used to
estimate filtration (eg, the established marker creatinine) or may precede and potentially
contribute to CKD development. Here, we applied a nontargeted metabolomics approach
using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small
molecules in human serum. The associations of these molecules with GFR estimated on the …
metabolite concentrations may result from impaired kidney function and can be used to
estimate filtration (eg, the established marker creatinine) or may precede and potentially
contribute to CKD development. Here, we applied a nontargeted metabolomics approach
using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small
molecules in human serum. The associations of these molecules with GFR estimated on the …