[HTML][HTML] Physical and functional interactions of neuronal growth suppressor necdin with p53
H Taniura, K Matsumoto, K Yoshikawa - Journal of Biological Chemistry, 1999 - ASBMB
Necdin is expressed in virtually all postmitotic neurons, and ectopic expression of this
protein suppresses cell proliferation. Necdin, like the retinoblastoma protein, interacts with
cell cycle promoting proteins such as simian virus 40 large T antigen, adenovirus E1A, and
the transcription factor E2F1. Here we demonstrate that necdin interacts with the tumor
suppressor protein p53 as well. The yeast two-hybrid and in vitro binding analyses revealed
that necdin bound to a narrow region (amino acids 35–62) located between the MDM2 …
protein suppresses cell proliferation. Necdin, like the retinoblastoma protein, interacts with
cell cycle promoting proteins such as simian virus 40 large T antigen, adenovirus E1A, and
the transcription factor E2F1. Here we demonstrate that necdin interacts with the tumor
suppressor protein p53 as well. The yeast two-hybrid and in vitro binding analyses revealed
that necdin bound to a narrow region (amino acids 35–62) located between the MDM2 …