[HTML][HTML] KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the …
KRAS codon 12 mutations are present in about 90% of ductal adenocarcinomas and in
undifferentiated carcinomas of the pancreas. The role of KRAS copy number changes and
resulting KRAS mutant allele-specific imbalance (MASI) in ductal adenocarcinoma (n= 94),
and its progression into undifferentiated carcinoma of the pancreas (n= 25) was studied by
direct sequencing and KRAS fluorescence in situ hybridization (FISH). Semi-quantitative
evaluation of sequencing electropherograms showed KRAS MASI (ie, mutant allele peak …
undifferentiated carcinomas of the pancreas. The role of KRAS copy number changes and
resulting KRAS mutant allele-specific imbalance (MASI) in ductal adenocarcinoma (n= 94),
and its progression into undifferentiated carcinoma of the pancreas (n= 25) was studied by
direct sequencing and KRAS fluorescence in situ hybridization (FISH). Semi-quantitative
evaluation of sequencing electropherograms showed KRAS MASI (ie, mutant allele peak …
