Increased 4–Hydroxynonenal Levels in Experimental Alcoholic Liver Disease: Association of Lipid Peroxidation With Liver Fibrogenesis
S Kamimura, K Gaal, RS Britton, BR Bacon… - Hepatology, 1992 - journals.lww.com
The precise role of lipid peroxidation in the pathogenesis of alcoholic liver disease is still
being debated. To explore the issue, this study was undertaken to investigate the status of
lipid peroxidation, antioxidants and prooxidants at two discrete stages of experimental
alcoholic liver disease. Male Wistar rats were intragastrically fed a high–fat diet plus ethanol
for 5 or 16 wk (the duration that resulted in initiation of centrilobular liver necrosis or liver
fibrosis, respectively). Lipid peroxidation was assessed in isolated microsomes and …
being debated. To explore the issue, this study was undertaken to investigate the status of
lipid peroxidation, antioxidants and prooxidants at two discrete stages of experimental
alcoholic liver disease. Male Wistar rats were intragastrically fed a high–fat diet plus ethanol
for 5 or 16 wk (the duration that resulted in initiation of centrilobular liver necrosis or liver
fibrosis, respectively). Lipid peroxidation was assessed in isolated microsomes and …