Background It is unclear why obesity is associated with worse asthma control. We
hypothesized that (1) obesity affects asthma control independent of spirometry, airway
inflammation, and airway hyperresponsiveness (AHR) and (2) residual symptoms after
resolution of inflammation are due to obesity-related changes in lung mechanics. Methods
Forty-nine subjects with asthma underwent the following tests, before and after 3 months of
high-dose inhaled corticosteroid (ICS) treatment: five-item asthma control questionnaire …