Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle
AF Roffel, CRS Elzinga, J Zaagsma - Pulmonary pharmacology, 1990 - Elsevier
The muscarinic receptor subtype involved in human airway smooth muscle contraction was
characterised for the first time, using subtype-selective muscarinic antagonists. It was
demonstrated that methacholine-induced contraction of central (trachea) and peripheral
(small bronchi) airway smooth muscle preparations was antagonised by pirenzepine, AF-DX
116, 4-DAMP methobromide, hexahydrosiladifenidol, and methoctramine with pA 2-values
characteristic of M 3 (smooth muscle/glandular) muscarinic receptors. Since these pA 2 …
characterised for the first time, using subtype-selective muscarinic antagonists. It was
demonstrated that methacholine-induced contraction of central (trachea) and peripheral
(small bronchi) airway smooth muscle preparations was antagonised by pirenzepine, AF-DX
116, 4-DAMP methobromide, hexahydrosiladifenidol, and methoctramine with pA 2-values
characteristic of M 3 (smooth muscle/glandular) muscarinic receptors. Since these pA 2 …
