[HTML][HTML] Structure-function analysis of Nel, a thrombospondin-1-like glycoprotein involved in neural development and functions
R Nakamura, C Nakamoto, H Obama… - Journal of Biological …, 2012 - ASBMB
Nel (neural epidermal growth factor (EGF)-like molecule) is a multimeric, multimodular
extracellular glycoprotein with heparin-binding activity and structural similarities to
thrombospondin-1. Nel is predominantly expressed in the nervous system and has been
implicated in neuronal proliferation and differentiation, retinal axon guidance, synaptic
functions, and spatial learning. The Nel protein contains an N-terminal thrombospondin-1
(TSP-N) domain, five cysteine-rich domains, and six EGF-like domains. However, little is …
extracellular glycoprotein with heparin-binding activity and structural similarities to
thrombospondin-1. Nel is predominantly expressed in the nervous system and has been
implicated in neuronal proliferation and differentiation, retinal axon guidance, synaptic
functions, and spatial learning. The Nel protein contains an N-terminal thrombospondin-1
(TSP-N) domain, five cysteine-rich domains, and six EGF-like domains. However, little is …