Purification and characterization of mouse hematopoietic stem cells
GJ Spangrude, S Heimfeld, IL Weissman - Science, 1988 - science.org
GJ Spangrude, S Heimfeld, IL Weissman
Science, 1988•science.orgMouse bone marrow hematopoietic stem cells were isolated with the use of a variety of
phenotypic markers. These cells can proliferate and differentiate with approximately unit
efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to
save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the
survivors.
phenotypic markers. These cells can proliferate and differentiate with approximately unit
efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to
save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the
survivors.
Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
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