[HTML][HTML] Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in …
We have previously shown that the human equilibrative nucleoside transporter 1 (hENT1) is
expressed and functional in the mitochondrial membrane and that this expression enhances
the mitochondrial toxicity of the nucleoside drug, fialuridine (FIAU)(Lai, Y., Tse, CM, and
Unadkat, JD (2004) J. Biol. Chem. 279, 4490–4497). Here we report on identification of the
mitochondrial targeting sequence of hENT1. Using confocal microscopy and different
truncated and point mutants of hENT1-YFP (yellow fluorescent protein) expressed in Madin …
expressed and functional in the mitochondrial membrane and that this expression enhances
the mitochondrial toxicity of the nucleoside drug, fialuridine (FIAU)(Lai, Y., Tse, CM, and
Unadkat, JD (2004) J. Biol. Chem. 279, 4490–4497). Here we report on identification of the
mitochondrial targeting sequence of hENT1. Using confocal microscopy and different
truncated and point mutants of hENT1-YFP (yellow fluorescent protein) expressed in Madin …