Triglyceride-rich lipoprotein remnants and cardiovascular disease
EK Duran, AD Pradhan - Clinical chemistry, 2021 - academic.oup.com
Clinical chemistry, 2021•academic.oup.com
Background Triglycerides, cholesterol, and their metabolism are linked due to shared
packaging and transport within circulating lipoprotein particles. While a case for a causal
role of cholesterol-carrying low-density lipoproteins (LDLs) in atherosclerosis is well made,
the body of scientific evidence for a causal role of triglyceride-rich lipoproteins (TRLs) is
rapidly growing, with multiple lines of evidence (old and new) providing robust support.
Content This review will discuss current perspectives and accumulated evidence that an …
packaging and transport within circulating lipoprotein particles. While a case for a causal
role of cholesterol-carrying low-density lipoproteins (LDLs) in atherosclerosis is well made,
the body of scientific evidence for a causal role of triglyceride-rich lipoproteins (TRLs) is
rapidly growing, with multiple lines of evidence (old and new) providing robust support.
Content This review will discuss current perspectives and accumulated evidence that an …
Background
Triglycerides, cholesterol, and their metabolism are linked due to shared packaging and transport within circulating lipoprotein particles. While a case for a causal role of cholesterol-carrying low-density lipoproteins (LDLs) in atherosclerosis is well made, the body of scientific evidence for a causal role of triglyceride-rich lipoproteins (TRLs) is rapidly growing, with multiple lines of evidence (old and new) providing robust support.
Content
This review will discuss current perspectives and accumulated evidence that an overabundance of remnant lipoproteins stemming from intravascular remodeling of nascent TRLs—chylomicrons and very low-density lipoproteins (VLDL)—results in a proatherogenic milieu that augments cardiovascular risk. Basic mechanisms of TRL metabolism and clearance will be summarized, assay methods reviewed, and pivotal clinical studies highlighted.
Summary
Remnant lipoproteins are rendered highly atherogenic by their high cholesterol content, altered apolipoprotein composition, and physicochemical properties. The aggregate findings from multiple lines of evidence suggest that TRL remnants play a central role in residual cardiovascular risk.
Oxford University Press