Lipoprotein lipase and its regulators: an unfolding story
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such
as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the
1940s, its biology and pathophysiological significance have been well characterized.
Nonetheless, several studies in the past decade, with recent delineation of LPL crystal
structure and the discovery of several new regulators such as angiopoietin-like proteins …
metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such
as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the
1940s, its biology and pathophysiological significance have been well characterized.
Nonetheless, several studies in the past decade, with recent delineation of LPL crystal
structure and the discovery of several new regulators such as angiopoietin-like proteins …
Lipoprotein lipase (LPL) is one of the most important factors in systemic lipid partitioning and metabolism. It mediates intravascular hydrolysis of triglycerides packed in lipoproteins such as chylomicrons and very-low-density lipoprotein (VLDL). Since its initial discovery in the 1940s, its biology and pathophysiological significance have been well characterized. Nonetheless, several studies in the past decade, with recent delineation of LPL crystal structure and the discovery of several new regulators such as angiopoietin-like proteins (ANGPTLs), glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), lipase maturation factor 1 (LMF1) and Sel-1 suppressor of Lin-12-like 1 (SEL1L), have completely transformed our understanding of LPL biology.
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