CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains
D Meyer, S Seth, J Albrecht, MK Maier… - Journal of Biological …, 2009 - jbc.org
The adhesion receptor CD96 (TACTILE) is a transmembrane glycoprotein possessing three
extracellular immunoglobulin-like domains. Among peripheral blood cells, CD96 is
expressed on T cells as well as NK cells and a subpopulation of B cells. A possible function
of this receptor in NK cell-mediated killing activities was suggested recently. Moreover,
CD96 was described as a tumor marker for T-cell acute lymphoblastic leukemia and acute
myeloid leukemia. CD96 binds to CD155 (poliovirus receptor) and nectin-1, an adhesion …
extracellular immunoglobulin-like domains. Among peripheral blood cells, CD96 is
expressed on T cells as well as NK cells and a subpopulation of B cells. A possible function
of this receptor in NK cell-mediated killing activities was suggested recently. Moreover,
CD96 was described as a tumor marker for T-cell acute lymphoblastic leukemia and acute
myeloid leukemia. CD96 binds to CD155 (poliovirus receptor) and nectin-1, an adhesion …
