Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing… - Annual review of …, 2020 - annualreviews.org
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a
functionally distinct T cell subpopulation actively engaged in the maintenance of
immunological self-tolerance and homeostasis. Recent studies have facilitated our
understanding of the cellular and molecular basis of their generation, function, phenotypic
and functional stability, and adaptability. It is under investigation in humans how functional …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a
functionally distinct T cell subpopulation actively engaged in the maintenance of
immunological self-tolerance and homeostasis. Recent studies have facilitated our
understanding of the cellular and molecular basis of their generation, function, phenotypic
and functional stability, and adaptability. It is under investigation in humans how functional …