Prednisolone decreases cellular adhesion molecules required for inflammatory cell infiltration in dystrophin-deficient skeletal muscle

M Wehling-Henricks, JJ Lee, JG Tidball - Neuromuscular Disorders, 2004 - Elsevier
The mechanism of prednisolone's efficacy in the dystrophic pathology is unclear.
Prednisolone's anti-inflammatory functions may be particularly important considering the
significance of inflammatory cells in dystrophinopathy. In other pathologies, prednisolone's
anti-inflammatory effects can be mediated by reducing cellular adhesion molecule (CAM)
expression. The goal of this study was to examine the effects of prednisolone on
inflammation and CAM expression in dystrophic muscle. Dystrophin-deficient, mdx mice …