Glucocorticoids exert a wide range of physiological effects, including the induction of
apoptosis in lymphocytes. The progression of glucocorticoid-induced apoptosis is a multi-
component process requiring contributions from both genomic and cytoplasmic signaling
events. There is significant evidence indicating that the transactivation activity of the
glucocorticoid receptor is required for the initiation of glucocorticoid-induced apoptosis.
However, the rapid cytoplasmic effects of glucocorticoids may also contribute to the …