[HTML][HTML] The bile acid TGR5 membrane receptor: from basic research to clinical application
H Duboc, Y Taché, AF Hofmann - Digestive and Liver Disease, 2014 - Elsevier
The TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first
identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely
distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord,
and the enteric nervous system. The effect of TGR5 activation depends on the tissue where it
is expressed and the signalling cascade that it induces. Animal studies suggest that TGR5
activation influences energy production and thereby may be involved in obesity and …
identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely
distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord,
and the enteric nervous system. The effect of TGR5 activation depends on the tissue where it
is expressed and the signalling cascade that it induces. Animal studies suggest that TGR5
activation influences energy production and thereby may be involved in obesity and …