Importance of large intestine in regulating bile acids and glucagon-like peptide-1 in germ-free mice
FP Selwyn, IL Csanaky, Y Zhang… - Drug Metabolism and …, 2015 - Elsevier
It is known that 1) elevated serum bile acids (BAs) are associated with decreased body
weight, 2) elevated glucagon-like peptide-1 (GLP-1) levels can decrease body weight, and
3) germ-free (GF) mice are resistant to diet-induced obesity. The purpose of this study was to
test the hypothesis that a lack of intestinal microbiota results in more BAs in the body,
resulting in increased BA-mediated transmembrane G protein–coupled receptor 5 (TGR5)
signaling and increased serum GLP-1 as a mechanism of resistance of GF mice to diet …
weight, 2) elevated glucagon-like peptide-1 (GLP-1) levels can decrease body weight, and
3) germ-free (GF) mice are resistant to diet-induced obesity. The purpose of this study was to
test the hypothesis that a lack of intestinal microbiota results in more BAs in the body,
resulting in increased BA-mediated transmembrane G protein–coupled receptor 5 (TGR5)
signaling and increased serum GLP-1 as a mechanism of resistance of GF mice to diet …