Shaping the nuclear action of NF-κB

LF Chen, WC Greene - Nature reviews Molecular cell biology, 2004 - nature.com
Nature reviews Molecular cell biology, 2004nature.com
Abstract The NF-κB/REL family of transcription factors pivotally control the inflammatory and
immune responses, as well as other genetic programmes that are central to cell growth and
survival. The cytoplasmic regulation of NF-κB is well characterized and, recently, significant
progress has been made in understanding how its nuclear action is regulated. Post-
translational modification of the NF-κB subunits as well as histones surrounding the NF-κB
target genes has a key role in this regulation. Here, we review the important advances that …
Abstract
The NF-κB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. The cytoplasmic regulation of NF-κB is well characterized and, recently, significant progress has been made in understanding how its nuclear action is regulated. Post-translational modification of the NF-κB subunits as well as histones surrounding the NF-κB target genes has a key role in this regulation. Here, we review the important advances that constitute this new and exciting chapter in NF-κB biology.
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