Complete nucleotide sequence of the antithrombin gene: evidence for homologous recombination causing thrombophilia
RJ Olds, DA Lane, V Chowdhury, V De Stefano… - Biochemistry, 1993 - ACS Publications
Biochemistry, 1993•ACS Publications
MATERIALS AND METHODS Antithrombin-Deficient Kindred. The propositus (G052)
suffered his first documented episode of thrombosis, affecting the dorsal vein of the penis, at
the age of 23 years. A further episode of superficial venous thrombosis occurred in the right
arm following injection of medication at the age of 46. The father of the propositus suffered
deep leg vein thrombosis and pulmonary embolism after prostatectomy at age 68. Two sons,
aged 17 and 20 years, havereduced levels of plasma antithrombin but as yet have had no …
suffered his first documented episode of thrombosis, affecting the dorsal vein of the penis, at
the age of 23 years. A further episode of superficial venous thrombosis occurred in the right
arm following injection of medication at the age of 46. The father of the propositus suffered
deep leg vein thrombosis and pulmonary embolism after prostatectomy at age 68. Two sons,
aged 17 and 20 years, havereduced levels of plasma antithrombin but as yet have had no …
MATERIALS AND METHODS
Antithrombin-Deficient Kindred. The propositus (G052) suffered his first documented episode of thrombosis, affecting the dorsal vein of the penis, at the age of 23 years. A further episode of superficial venous thrombosis occurred in the right arm following injection of medication at the age of 46. The father of the propositus suffered deep leg vein thrombosis and pulmonary embolism after prostatectomy at age 68. Two sons, aged 17 and 20 years, havereduced levels of plasma antithrombin but as yet have had no clinically symptomatic thrombotic events. A reduction in plasma antithrombinof
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