Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule.
RM Brodbeck, JL Brown - Journal of Biological Chemistry, 1992 - jbc.org
In the human disease alpha-1-proteinase inhibitor deficiency, some variants of human alpha-
1-proteinase inhibitor are not secreted. These secretory variants contain frameshift
mutations leading to products with normal amino acid sequences to the points of the
mutations followed by short, aberrant C-terminal sequences and then premature termination
(Nukiwa, T., Takahashi, H., Brantly, M., Courtney, M., and Crystal, R.(1987) J. Biol. Chem.
262, 11999-12004; Sifers, RN, Brashears-Macatee, S., Kidd, VJ, Muensch, H., and Woo …
1-proteinase inhibitor are not secreted. These secretory variants contain frameshift
mutations leading to products with normal amino acid sequences to the points of the
mutations followed by short, aberrant C-terminal sequences and then premature termination
(Nukiwa, T., Takahashi, H., Brantly, M., Courtney, M., and Crystal, R.(1987) J. Biol. Chem.
262, 11999-12004; Sifers, RN, Brashears-Macatee, S., Kidd, VJ, Muensch, H., and Woo …
