[HTML][HTML] The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells
MJ Robinson, P Tessier, R Poulsom, N Hogg - Journal of Biological …, 2002 - ASBMB
The S100 family proteins MRP-8 (S100A8) and MRP-14 (S100A9) form a heterodimer that is
abundantly expressed in neutrophils, monocytes, and some secretory epithelia. In inflamed
tissues, the MRP-8/14 complex is deposited onto the endothelium of venules associated
with extravasating leukocytes. To explore the receptor interactions of MRP-8/14, we use a
model system in which the purified MRP-8/14 complex binds to the cell surface of an
endothelial cell line, HMEC-1. This interaction is mediated by the MRP-14 subunit and is …
abundantly expressed in neutrophils, monocytes, and some secretory epithelia. In inflamed
tissues, the MRP-8/14 complex is deposited onto the endothelium of venules associated
with extravasating leukocytes. To explore the receptor interactions of MRP-8/14, we use a
model system in which the purified MRP-8/14 complex binds to the cell surface of an
endothelial cell line, HMEC-1. This interaction is mediated by the MRP-14 subunit and is …