VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Journal of Cell Biology, 2003•rupress.org
V respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs
in the sprout stalks. These two cellular responses are both mediated by agonistic activity of
VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A,
proliferation is regulated by its concentration. Thus, vessel patterning during retinal
angiogenesis depends on the balance between two different qualities of the extracellular
VEGF-A distribution, which regulate distinct cellular responses in defined populations of …
in the sprout stalks. These two cellular responses are both mediated by agonistic activity of
VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A,
proliferation is regulated by its concentration. Thus, vessel patterning during retinal
angiogenesis depends on the balance between two different qualities of the extracellular
VEGF-A distribution, which regulate distinct cellular responses in defined populations of …
V respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks. These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration. Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells.
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