Notch3 is a major regulator of vascular tone in cerebral and tail resistance arteries.: Notch3 and vascular tone
EJB de Chantemèle, K Retailleau, F Pinaud… - 2008 - policycommons.net
OBJECTIVE: Notch3, a member of the evolutionary conserved Notch receptor family, is
primarily expressed in vascular smooth muscle cells. Genetic studies in human and mice
revealed a critical role for Notch3 in the structural integrity of distal resistance arteries by
regulating arterial differentiation and postnatal maturation. METHODS AND RESULTS: We
investigated the role of Notch3 in vascular tone in small resistance vessels (tail and cerebral
arteries) and large (carotid) arteries isolated from Notch3-deficient mice using arteriography …
primarily expressed in vascular smooth muscle cells. Genetic studies in human and mice
revealed a critical role for Notch3 in the structural integrity of distal resistance arteries by
regulating arterial differentiation and postnatal maturation. METHODS AND RESULTS: We
investigated the role of Notch3 in vascular tone in small resistance vessels (tail and cerebral
arteries) and large (carotid) arteries isolated from Notch3-deficient mice using arteriography …
