Crosstalk between (Pro) renin receptor and COX-2 in the renal medulla during angiotensin II-induced hypertension
T Yang - Current opinion in pharmacology, 2015 - Elsevier
Highlights•AngII infusion induces parallel increases in renal medullary expression of PRR
and COX-2.•PRR activation increases PGE 2 release and COX-2 expression via
ERK1/2.•COX-2-derived PGE 2 via EP 4 stimulates PRR expression and renin activity.•The
interaction of PRR and COX-2 is a key to AngII-induced renin response in the distal
nephron.Angiotensin II (AngII) is an octapeptide hormone that plays a central role in
regulation of sodium balance, plasma volume, and blood pressure. Its role in the …
and COX-2.•PRR activation increases PGE 2 release and COX-2 expression via
ERK1/2.•COX-2-derived PGE 2 via EP 4 stimulates PRR expression and renin activity.•The
interaction of PRR and COX-2 is a key to AngII-induced renin response in the distal
nephron.Angiotensin II (AngII) is an octapeptide hormone that plays a central role in
regulation of sodium balance, plasma volume, and blood pressure. Its role in the …
