Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A
MC Whelan, DR Senger - Journal of Biological Chemistry, 2003 - jbc.org
Collagen I provokes endothelial cells to assume a spindle-shaped morphology and to align
into solid cord-like assemblies. These cords closely imitate the solid pre-capillary cords of
embryonic angiogenesis, raising interesting questions about underlying mechanisms.
Studies described here identify a critical mechanism beginning with collagen I ligation of
integrins α 1 β 1 and α 2 β 1, followed by suppression of cyclic AMP and cyclic AMP (cAMP)-
dependent protein kinase A, and marked induction of actin polymerization to form prominent …
into solid cord-like assemblies. These cords closely imitate the solid pre-capillary cords of
embryonic angiogenesis, raising interesting questions about underlying mechanisms.
Studies described here identify a critical mechanism beginning with collagen I ligation of
integrins α 1 β 1 and α 2 β 1, followed by suppression of cyclic AMP and cyclic AMP (cAMP)-
dependent protein kinase A, and marked induction of actin polymerization to form prominent …