Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors
T Subkhankulova, X Zhang, C Leung… - Molecular and Cellular …, 2010 - Elsevier
Bmi1, the main component of the Polycomb repressive complex 1, plays a key role in self-
renewal of stem cells as well as in proliferation of progenitor cells and senescence, at least
in part through inhibition of the Cdkn2a locus. Bmi1 is highly expressed in the developing
cerebellum, where it contributes to Shh-mediated expansion of granule cell precursors.
Overexpression of Bmi1 has been described in medulloblastoma, highly aggressive brain
neoplasms of childhood, which are thought to originate from deregulated proliferation of …
renewal of stem cells as well as in proliferation of progenitor cells and senescence, at least
in part through inhibition of the Cdkn2a locus. Bmi1 is highly expressed in the developing
cerebellum, where it contributes to Shh-mediated expansion of granule cell precursors.
Overexpression of Bmi1 has been described in medulloblastoma, highly aggressive brain
neoplasms of childhood, which are thought to originate from deregulated proliferation of …
