Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic
ageing processes act on the dermis, a post-mitotic skin compartment mainly consisting of
extracellular matrix and fibroblasts. Dermal fibroblasts are long-lived cells constantly
undergoing damage accumulation and (mal-) adaptation, thus constituting a powerful
indicator system for human ageing. Here, we use the systematic of ubiquitous hallmarks of …