Thy-1 knockdown retards wound repair in mouse skin
MJ Lee, JO Shin, HS Jung - Journal of dermatological science, 2013 - Elsevier
BACKGROUND: Thy-1 (CD90) is a glycophosphatidyl-inositol (GPI) linked, cell surface
glycoprotein located in non-caveolar lipid raft microdomains. OBJECTIVE: The biological
functions of Thy-1 in many tissues are well known, however, its role in skin wound healing
remains unclear. METHODS AND RESULTS: In fibroblasts cells, Thy-1 affects cell migration
into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly
expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process …
glycoprotein located in non-caveolar lipid raft microdomains. OBJECTIVE: The biological
functions of Thy-1 in many tissues are well known, however, its role in skin wound healing
remains unclear. METHODS AND RESULTS: In fibroblasts cells, Thy-1 affects cell migration
into the wound, cell proliferation and the cytoskeleton structure. Additionally, Thy-1 is mainly
expressed in the wound dermis. Here, we compared the in vivo aspects of the repair process …