[HTML][HTML] Pneumocystis carinii cell wall β-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated …

PY Hahn, SE Evans, TJ Kottom, JE Standing… - Journal of Biological …, 2003 - ASBMB
Infiltration of the lungs with neutrophils promotes respiratory failure during
severePneumocystis carinii (PC) pneumonia. Recent studies have shown that alveolar
epithelial cells (AECs), in addition to promoting PC attachment, also participate in lung
inflammation by the release of cytokines and chemokines. Herein, we demonstrate that a PC
β-glucan rich cell wall isolate (PCBG) stimulates the release of macrophage inflammatory
protein-2 (MIP-2) from isolated AECs through a lactosylceramide-dependent mechanism …