Aspergillus fumigatus triggers innate immune response via NOD1 signaling in human corneal epithelial cells
Y Zhang, J Wu, Z Xin, X Wu - Experimental eye research, 2014 - Elsevier
Fungal keratitis is a serious vision-threatening disease caused by fungi after corneal
epithelium damage. We have previously shown a role of cell surface TLRs in Aspergillus
fumigatus (A. fumigatus) keratitis. In the present study we showed that Human telomerase-
immortalized corneal epithelial cells (HCECs) exposed to A. fumigatus elicited an
inflammatory response consisting in increased interleukin-6 (IL-6), IL-8 and tumor necrosis
factor (TNF)-α expression and innate defense molecules hBD2 and LL37 in a time …
epithelium damage. We have previously shown a role of cell surface TLRs in Aspergillus
fumigatus (A. fumigatus) keratitis. In the present study we showed that Human telomerase-
immortalized corneal epithelial cells (HCECs) exposed to A. fumigatus elicited an
inflammatory response consisting in increased interleukin-6 (IL-6), IL-8 and tumor necrosis
factor (TNF)-α expression and innate defense molecules hBD2 and LL37 in a time …